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This review systematically summarized LC-associated psychological symptoms, including social stigma and shame, anxiety and depression, PTSD, fatigue, sleep disturbances, and cognitive dysfunction, all of which significantly reduce patients quality of life and social functioning

As most of the studies showed herein about the beneficial effects of pycnogenol has been participated either in vitro , using cell cultures, or utilizing various animal models, additional data on its beneficial activity and exact molecular mechanisms in humans must be warranted

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Or the participant might be on a medication that can react to the new drugs active ingredient which would also disqualify them